Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-812-5 | CAS number: 110-88-3
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- 84 patients with contact dermatitis were patch tested with trioxane.
The purpose of the present study was to determine the relative share of irritant and allergic contact dermatitis in stomatological staff.
Test material
- Reference substance name:
- 1,3,5-trioxane
- EC Number:
- 203-812-5
- EC Name:
- 1,3,5-trioxane
- Cas Number:
- 110-88-3
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 1,3,5-trioxane
- Details on test material:
- Trioxymethylene (trioxane), 5% in petrolatum.
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- 84 patients with contact dermatitis (38 dentists, 18 nurses and 28 dental technieans).
- Clinical history:
- All the patients had eruptions localised mainly on the hands, more often bilaterally, but sometimes involving the forearms and the face.
They all were questioned about the time of onset of the disease to situate it chronologically before or after the beginning of their practice. Data were collected concerning improvement during interruptions in their work. Persons with past or present atopic dermatitis or atopic mucosal symptoms (allergic, rhinitis, conjunctivitis or asthma) were regarded as atopics. - Route of administration:
- dermal
Results and discussion
- Results of examinations:
- 31 persons (36.9 %) were diagnosed as having an occupational allergie contact dermatitis (12 dentists, including 4 dental surgeons, 9 nurses and 10 dental teclmicians).
One dental nurse (1.2%) showed indications for an allergy against trioxane.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
