Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-509-5 | CAS number: 96-48-0
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis:
- Occurs slowly under acidic conditions
- Occurs rapidly under basic conditions
Key value for chemical safety assessment
Additional information
According to studies conducted by U.S. Food and Drug Administration (Ciolino, L.A., 2001), the pH-hydrolysis studies showed that γ-Butyrolactone (GBL) hydrolysis occurs under acidic, basic, and neutral conditions with the rate and extent of conversion to GHB varying widely according to the solution pH. At ambient temperature, and under strongly alkaline conditions (pH 12.0), the conversion time frame was within minutes, with 100% conversion to GHB. Under strongly acidic conditions (pH 2.0), the conversion time frame was days with the formation of an equilibrium mixture comprising ca. 2:1 GBL:GHB. In pure water, the same ca. 2:1 GBL:GBH equilibrium mixture was ultimately formed with gradual conversion occurring over more than six months storage (202 days) at ambient temperature. At intermediate pH’s (pH 4.0 to 7.0), conversion to GHB occurred continually over several months, with the extent of conversion ranging from 72 to 97% after ca. seven months of storage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
