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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was conducted in 1959. It is not a guideline study and is non-GLP.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The test material prepared as a suspension in peanut oil was placed in contact with intact abdominal skin of rabbits for 6 hours
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Rats were exposed for 7h to varying amounts of test substance (AN-33) 3.2 to 10 ml per kg.
Duration of exposure:
7 hours
Doses:
3.2 to 10 ml per kg
No. of animals per sex per dose:
No data
Control animals:
no
Details on study design:
No details

Results and discussion

Preliminary study:
The rats had no local injuries and showed no signs of systemic illness following dermal exposure.
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD0
Effect level:
10 mL/kg bw
Based on:
other: technical containing 70-80% 2,6-di-tert-butylphenol
Mortality:
None
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Not classified for dermal toxicity.