Registration Dossier
Registration Dossier
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EC number: 270-608-0 | CAS number: 68457-79-4
Endpoint summary
Administrative data
Description of key information
The test material is not acute toxic.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 600 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 20 000 mg/kg bw
Additional information
This substance does not show any evidence of toxicity via the oral route of exposure in animals when tested in accordance with OECD Guideline 401. The rat oral LD50 is 3,600 mg/kg in male rats. Sublethal effects of lethargy, diarrhea, piloerection, chromodacryorrhea, chromorhinorrhea and ptosis were observed. Necropsy observations included lung and gastrointestinal abnormalities, but no specific organ toxicity is significant;all animals showed expected bodyweight gain during the course of study.
This substance does not show adverse toxicity effects via the dermal route of exposure in animals when tested in accordance with OECD Guideline 402. The rat dermal LD50 is greater than 20,000 mg/kg in rabbits. No mortality occurred. Toxic signs observed included lethargy, diarrhea, ataxia, ptosis, alopecia, emaciation, and yellow nasal discharge. No specific organ toxicity is evident.
Justification for classification or non-classification
In accordance to Directive 67/548/EEC and EU CLP (Regulation (EC) No. 1272/2008), classification of this substance is not required for acute toxicity.
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