Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-859-9 | CAS number: 100-51-6
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- other: reviewed data on dermal absorption
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: reviewed data on dermal absorption
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Benzylalcohol
- Author:
- DFG (Deutsche Forschungsgemeinschaft/German Research Foundation)
- Year:
- 2 006
- Bibliographic source:
- MAK value documentation on benzyl alcohol; The MAK Collection for Occupational Health and Safety, Wiley Online Library (http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb10051d0040/pdf; only available in German)
- Reference Type:
- publication
- Title:
- In vivo percoutaneous absorption of fragance ingredientts in rhesus monkeys and humans
- Author:
- Bronaugh RL, Wester RC, Bucks D, Maibach HI, Sarason R cited in DFG 2006
- Year:
- 1 990
- Bibliographic source:
- Fd Chem Toxicol 28,369-373
Materials and methods
- Principles of method if other than guideline:
- acccording to the method of Wester and Maibach(1975) Toxicol Appl Pharmacol 32, 394-398
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzyl alcohol
- EC Number:
- 202-859-9
- EC Name:
- Benzyl alcohol
- Cas Number:
- 100-51-6
- Molecular formula:
- C7H8O
- IUPAC Name:
- phenylmethanol
- Details on test material:
- purity 97 %
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- monkey
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- other: occlusive and open
- Vehicle:
- acetone
- Duration of exposure:
- 24 hours
- Doses:
- 4 µg/cm²
- No. of animals per group:
- no data
- Control animals:
- no
- Remarks:
- no data
Results and discussion
Percutaneous absorptionopen allclose all
- Dose:
- of the applied dose
- Parameter:
- percentage
- Absorption:
- ca. 32 %
- Remarks on result:
- other: in 24 h
- Remarks:
- unoccluded conditions
- Dose:
- applied dose
- Parameter:
- percentage
- Absorption:
- ca. 56 - <= 80 %
- Remarks on result:
- other: in 24 h
- Remarks:
- Absorption through occluded skin was high (56-80 %) in 24 h.
- Conversion factor human vs. animal skin:
- no data
Any other information on results incl. tables
RM-Freetext: Benzyl alcohol as a fragrance ingredient used in cosmetic and other products is lipophilic and therefore has the potential to be readily absorbed through skin. The percutaneous absorption was determined in vivo in rhesus monkeys. Absorption through occluded skin was high (56-80 %) in 24 h. No correlation was seen between skin penetration and the octanol-water partition coefficient. Under unoccluded conditions skin penetration was reduced (32 %), because of evaporation of the compound.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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