Registration Dossier
Registration Dossier
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EC number: 260-599-1 | CAS number: 57158-29-9
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: three reliable, guideline conform studies (OECD 401) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (powder and solution form). All studies indicate a low acute oral toxicity, with the LD50 larger than the limit dose, i.e. > 2000 mg/kg.
Acute inhalation toxicity: Based on uses and particle size consideration, the potential for inhalation exposure is low for aluminium zirconium chloride hydroxide (dermal and oral exposure more relevant).
Acute dermal toxicity: two reliable, guideline conform studies (OECD 402) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (solution form). Both studies indicate a low acute dermal toxicity, with the LD50 larger than the limit dose, i.e. > 2000 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Justification for classification or non-classification
Acute oral toxicity: three reliable, guideline conform studies (OECD 401) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (powder and solution form). All studies indicate a low acute oral toxicity, with the LD50 larger than the limit dose, i.e. > 2000 mg/kg.
Acute inhalation toxicity: Based on uses and particle size consideration, the potential for inhalation exposure is low for aluminium zirconium chloride hydroxide (dermal and oral exposure more relevant).
Acute dermal toxicity: two reliable, guideline conform studies (OECD 402) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (solution form). Both studies indicate a low acute dermal toxicity, with the LD50 larger than the limit dose, i.e. > 2000 mg/kg.
Based on this data, classification for acute toxicity is not requried.
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