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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
supporting study
Study period:
1950
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The original reference is not available. This study was not conducted according to GLP standard.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
SIDS Initial Assessment Report for SIAM 22, 4,4'-Oxybis (benzenesulfonyl hydrazide) (OBSH)
Author:
OECD
Year:
2006
Bibliographic source:
OECD SIDS Assessment Report

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: FIFRA Section 162.8 (c), March 1948
Deviations:
not specified
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Details on dermal exposure:
The calculated dosage was first dissolved in distilled water and then placed onto gauze squares. The squares were immediately placed on the bare skin of each rabbit and securely held in place with waterproof adhesive tape. Care was taken to completely cover each patch securely so as to minimize evaporation and to insure continuous contact with the skin for 24 hours.
Duration of exposure:
24 hours
Doses:
200 mg/kg
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Preliminary study:
NA
Mortality:
All animals were alive and well after the 24 hour period.
Clinical signs:
No toxic manifestations were exhibited by any of the animals under the test.
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal acute toxicity of OBSH was evaluated in rabbit. The rabbits skin were in contact with a dose of 200mg/kg for 24 hours continuously.

The following observations were made after 24 hour exposure:
- All animals were alive and well after the 24 hour period
- No toxic manifestations were exhibited by any of the animals under the test.
Executive summary:

The dermal acute toxicity of OBSH was evaluated in rabbit. The rabbits skin were in contact with a dose of 200 mg/kg for 24 hours continuously.

The following observations were made after 24 hour exposure:

- All animals were alive and well after the 24 hour period

- No toxic manifestations were exhibited by any of the animals under the test.