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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1973
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)
Deviations:
yes
Remarks:
Only 5 days and 6 rabbits
Principles of method if other than guideline:
0.5 mL of 5 or 10% suspensions of C.I. Pigment Orange 5 in sesame oil was applied daily for 5 days on the skin of 6 depilated rabbits
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rabbit
Strain:
other: Gelb-Silver

Administration / exposure

Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
daily exposure for 5 days
Frequency of treatment:
daily
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
0.5 mL of 5% suspension of C.I. Pigment Orange 5 in sesame oil
Basis:
other:
Remarks:
Doses / Concentrations:
0.5 mL of 10% suspension of C.I. Pigment Orange 5 in sesame oil
Basis:
other:
No. of animals per sex per dose:
3

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
> 50 other: mg/day
Based on:
test mat.
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
No NOAEL was identified