Registration Dossier
Registration Dossier
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EC number: 212-222-7 | CAS number: 770-35-4
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity studies have been conducted in fish, daphnia and algae. The EC50s/LC50s for propylene glycol phenyl ether is 280 mg/L for fish (Fathead minnow), 370mg/L for Daphnia and >100 mg/L in algae, while the algal NOEC was 55.5 mg/L. Since 42.7% inhibition of the growth rate was observed at the highest tested concentration of 100 mg/L, this concentration will be considered as a conservative estimation of the algal EC50, which indicates that alga was the most sensitive species tested. This value will therefore be used in the PNEC derivation. The EC50 determined in a respiration inhibition test according is greater than 1000 mg/L. Propylene glycol phenyl ether is readily biodegradable and has very low potential for bioaccumulation (log Kow <2). According to REACH Annex IX requirements, long-term toxicity testing shall only be considered when the chemical safety assessment indicates the need for further investigations. Hence, long-term testing in aquatic species (fish and invertebrate) can be waived.
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