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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data available as short summary from a secondary source beeing cited in a peer-reviewed publication

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acute toxicity studies in rats, mice, rabbits and guinea pigs
Author:
Moreno OM,
Year:
1976
Bibliographic source:
Unpublished report to RIFM; Tetrahydrolinalool CAS 78-69-3 RIFM ID 773 FEMA 3060
Reference Type:
secondary source
Title:
Acute toxicity studies in rats, mice, rabbits and guinea pigs
Author:
Moreno OM
Year:
1976
Bibliographic source:
cited in: Opdyke DJM, Food Cosmet. Toxicol., Vol 17, p. 909, 1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A dermal LD50 study was conducted in which 5 g/kg of the test material was applied to the skin of 10 rats. The animals were observed for mortality and/or systemic effects for 14 days. No further details were provided.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7-dimethyloctan-3-ol
EC Number:
201-133-9
EC Name:
3,7-dimethyloctan-3-ol
Cas Number:
78-69-3
Molecular formula:
C10H22O
IUPAC Name:
3,7-dimethyloctan-3-ol
Details on test material:
- Name of test material (as cited in study report): Tetrahydrolinalool = THL

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw

Applicant's summary and conclusion