3,7-dimethyloctan-3-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Method: BASF-Test; The test was performed according to Smith et al. (1944). J. Ind. Hyg. Tox. 26: 269 (In principle as described in OECD Guideline 403, from 12 May 1981)

GLP compliance:

no

Test type:

other: inhalation hazard test

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethyloctan-3-ol

EC Number:

201-133-9

EC Name:

3,7-dimethyloctan-3-ol

Cas Number:

78-69-3

Molecular formula:

C10H22O

IUPAC Name:

3,7-dimethyloctan-3-ol

Details on test material:

- Name of test material (as cited in study report): Tetrahydrolinalool (THL); Substance-ID: XXVI 402
- Physical state: fluid
- Analytical purity: > 98%
- Molecular weight (if other than submission substance): 158 g/mol
- Other: pH 7
- Solubility: water: no; alcohol: yes

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: test 1: males 247 g, females 186 g; test 2: males 243 g, females 189 g

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- A saturated atmosphere was generated by bubbling 200 l/h air at 20 ° C through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 hours.

TEST ATMOSPHERE
- No analytical determination of the atmosphere concentration was performed. The nominal concentration was calculated as the quotient of the amount of test substance weight loss during the exposure and the amount of air used during the exposure.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

saturated atmosphere

No. of animals per sex per dose:

6 males, 6 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 2 days
- Observations: on day 0 and day1
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.885 mg/L air

Remarks on result:

other: Nominal concentration, not analytically verified

Mortality:

0/12

Clinical signs:

other: Nothing abnormal detected

Body weight:

Test 2:
males: mean body weights prior to the experiment: 243 g; day 1 of the experiment: 290 g;
females: mean body weights prior to the experiment: 189 g; day 1 after the experiment : 212 g
no further data given

Gross pathology:

Nothing abnormal detected

Any other information on results incl. tables

mean substance concentration (calculated):

1.39 g/1600 l air = 0.87 mg/l air (on day 02.02.1977) (3 males and 3 females used)

1.44 g/1600 l air = 0.90 mg/l air (on day 03.02.1977) (3 males and 3 females used)

overall mean: 0.885 mg/l air