Registration Dossier
Registration Dossier
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EC number: 213-912-0 | CAS number: 1066-35-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to microorganisms: 3hr ASRI NOEC 32 mg/l (OECD 209) for read-across substance dichloro(methyl)silane
Key value for chemical safety assessment
Additional information
No reliable data are available for the toxicity to microorganisms of chlorodimethylsilane. A toxicity to microorganisms study is, however, available for the related substance dichloro(methyl)silane. It is considered appropriate to read across the toxicity to microorganisms result for dichloro(methyl)silane because it is considered a close structural analogue of chlorodimethylsilane. Both chlorodimethylsilane and dichloro(methyl)silane will hydrolyse very rapidly under conditions relevant to microbial toxicity assessment, to similar hydrolysis products, dimethylsilanol and methylsilanediol, respectively. The other hydrolysis product is HCl. Effects of hydrogen chloride on microorganisms are limited to those that result from changes to pH in unbuffered media. In this study it is likely that the inhibition was influenced by the low pH levels at the higher loading rates, but the pH at the NOEC was 7, and therefore the NOEC is considered the most useful and representative result.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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