Registration Dossier
Registration Dossier
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EC number: 224-052-0 | CAS number: 4180-23-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Food Flavourings and Compounds of Related Structure I. Acute Oral toxicity
- Author:
- P.M. Jennes, E.C. Hagan, Jean M. Taylor, E.L. Cook and O.G. Fitzhugh
- Year:
- 1 964
- Bibliographic source:
- Fd Cosmet. Toxicol. Vol. 2, pp. 327-343. Pergamon Press
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (E)-anethole
- EC Number:
- 224-052-0
- EC Name:
- (E)-anethole
- Cas Number:
- 4180-23-8
- Molecular formula:
- C10H12O
- IUPAC Name:
- 1-methoxy-4-prop-1-en-1-ylbenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: intubation
- Vehicle:
- unchanged (no vehicle)
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 1 420 - <= 3 070 mg/kg bw
- Based on:
- not specified
- 95% CL:
- ca. 2 090
- Mortality:
- Death Time: 1-3 days
- Clinical signs:
- other: Low doses--depression, high doses--coma
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- As LD50>2000mg/kg bw, the substance is not classified under CLP Regulation.
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