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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Amides, C18-unsatd., N-[3-(dimethylamine)propyl] were found to be very toxic to fish with EC50 of 0.94 mg/L, expressed as nominal concentrations. 

Key value for chemical safety assessment

LC50 for freshwater fish:
0.94 mg/L

Additional information

The acute toxicity of Amides, C18-unsatd., N-[3-(dimethylamine)propyl] to the fresh water fish Danio rerio (zebra fish) was tested under semi static conditions,with refreshment after 48 hours in natural water for 96 hours in accordance with the OECD and EEC guidelines for testing of chemicals, with minor modifications. The test wasperformed in compliance with Good Laboratory Practice (GLP).

 

The definitive test was performed with the following nominal test concentrations including a control: 0.2, 0.45, 1.0, 2.2 and 4.4 mg/L.

 The NOEC for the test substance was determined as 0.45 mg/L. The LC50calculated using the Spearman Karber Graphical Method was a 0.94 mg/L.

 

Chemical analysis of the initial concentrations of the test chemical was carried out at all concentrations and in the stock solutions. Recovery of the test chemical after 48 hours was not possible due to inherent test chemical properties. Endpoints were therefore based on nominal values confirmed by the initial analytical recoveries of >90% of the nominal concentrations, in line with the bulk approach.