Registration Dossier

Administrative data

Description of key information

SKIN: Tested in rabbits, nickel sulphate was not a skin irritant. However, human data indicate that nickel sulphate in concentrations above 20% can induce skin irritation. 
EYE: Zinc sulphate is an eye irritant in experimental animals.
RESPIRATORY: The available data do not allow any conclusion on respiratory irritation.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

Ni sulfate is classified as Xi: R38 and Skin Irrit. 2: H315 in the 1st ATP to the CLP Regulation. Background information regarding this classification has been provided in the discussion section above.

Zn sulfate is classified for eye irritation based on experimental data in animals.