Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publicationthat meets basic scientific principle but no standard test

Data source

Reference
Reference Type:
publication
Title:
Cadmium toxicity and accumulation in eggs and alevins of Atlantic salmon Salmo salar
Author:
Rombough & garside
Year:
1982
Bibliographic source:
Can. J. Zool. 60(8): 2006-2014

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
24d mortality test on juveniles
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
none

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
no
Details on test solutions:
Municipal water charcoal filtered and UV sterilised.

Test organisms

Test organisms (species):
Salmo salar
Details on test organisms:
TEST ORGANISM
- Common name: Atlantic salmon
- Source: newly hatched alevins from fish culture station
- habitat concentration 1-14 µg/L

Study design

Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
24 d

Test conditions

Hardness:
19-28 mg CaCO3/l
Test temperature:
5-10 °C
pH:
6.5 to7.3
Dissolved oxygen:
11.1 to 12.5 mg O2/l
Salinity:
N/A
Nominal and measured concentrations:
control - 0.32 - 1 - 3.2 - 10 - 32 - 100 - 320 - 1000 - 3200 - 10000 - 320000 µg Cd/L
Details on test conditions:
Alcalinity 14-17 mg CaCO3/L
Background concentration = 0.13 µg Cd/L
Reference substance (positive control):
no

Results and discussion

Effect concentrations
Duration:
24 d
Dose descriptor:
LC50
Effect conc.:
34 µg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
dissolved
Basis for effect:
mortality
Reported statistics and error estimates:
Alevin survival data were analysed with Biomedical survivorship program (BMD 01S)

Any other information on results incl. tables

none

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Test is not done according to standard protocol but is of good quality and considered useful for setting the reference value for acute aquatic ecotoxicity. The study was used for that purpose in the EU risk assessment process on cadmium (ECB 2008).
Executive summary:
Tests not done according to standard protocol, but of good quality and considered useful for setting the reference value for acute aquatic ecotoxicity. Study used for that purpose in the EU risk assessment process on cadmium (ECB 2008). Culture medium, test water conditions well described and relevant the purpose of classification.