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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
Reported on 29 March 1972
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study information largely restricted to provision of results with no details on methods. Completed prior to adoption of GLP principles or standardised test guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute study conducted to standard methods using intraperitoneal route of administration. Study completed prior to adoption of international test guidelines.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl benzoate
EC Number:
204-402-9
EC Name:
Benzyl benzoate
Cas Number:
120-51-4
Molecular formula:
C14H12O2
IUPAC Name:
benzyl benzoate
Test material form:
not specified
Details on test material:
no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
No further details

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: reported as Cremophor EL, but this is more probably the vehicle for oral administration
Details on exposure:
No details provided in report
Doses:
No details given in report
No. of animals per sex per dose:
10 males
Control animals:
not specified
Details on study design:
Standard acute design in single sex, similar to methods subsequently laid out in OECD Guideline 401
Statistics:
No details of derivation of median lethal dose and fiducial limits

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 078 mg/kg bw
Based on:
test mat.
95% CL:
> 928 - < 1 261
Mortality:
Death occurred one hour after dose administration but the numbers of mortalities are not recorded in the report summary
Clinical signs:
No signs reported for rats dosed by i.p. route
Body weight:
No data
Gross pathology:
No abnormalities detected
Other findings:
no data

Applicant's summary and conclusion

Conclusions:
The median lethal dose following intraperitoneal injection to male rats was 1078 mg/kg bw. Death occurred an hour following dosing but no further details are available.
Executive summary:

In an acute intraperitoneal injection study rats were administered varous unspecified doses and mortality checked to determine the median lethal i.p. dose. The median lethal dose following intraperitoneal injection to male rats was 1078 mg/kg bw. Death occurred an hour following dosing but no further details are available.