Registration Dossier
Registration Dossier
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EC number: 204-402-9 | CAS number: 120-51-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Published study with limited details relating to methods. Study pre-dates adoption of regulatory test guidelines.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological investigation of compounds proposed for use as insect repellents. A. Local and systemic effects following topical skin application
- Author:
- Draize JH, Alvarez E & Whitesell MF
- Year:
- 1 947
- Bibliographic source:
- J Pharmac Exp Ther 3(26): 26-39
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Screening test
- GLP compliance:
- no
- Test type:
- other: Draize primary skin irritation screening test
- Limit test:
- yes
Test material
- Reference substance name:
- Benzyl benzoate
- EC Number:
- 204-402-9
- EC Name:
- Benzyl benzoate
- Cas Number:
- 120-51-4
- Molecular formula:
- C14H12O2
- IUPAC Name:
- benzyl benzoate
- Test material form:
- other: liquid
- Details on test material:
- No details provided in publication
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No details provided
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No details provided for method of application
- Duration of exposure:
- Not specified in publication, normal exposure period in Draize method is 4 hours.
- Doses:
- 2.0 mL/kg bw
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No information
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths occurred
- Mortality:
- No mortality in skin irritation tests.
Benzyl benzoate displays a toxic threshold with a sharp demarcation at circa 2.0 mL/kg bw. Delayed deaths occurred following a single high dose topical application. Animals that died exhibited no clinical signs prior to death. - Clinical signs:
- other: No signs of systemic toxicity observed
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 of benzyl benzoate was found to be >2 mL/kg bw (~2000 mg/kg bw) under the conditions of this assay.
- Executive summary:
The acute dermal LD50 of benzyl benzoate was investigated in a screening assay in the rabbit and was found to be >2 mL/kg bw (~2000 mg/kg bw).
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