4,4'-Isopropylidenediphenol, ethoxylated

Biodegradation in water and sediment: simulation tests

Link to relevant study record(s)

Reference

Endpoint:

biodegradation in water: simulation testing on ultimate degradation in surface water

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 2021 with completion expected in October 2021 for the OECD 309

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 309 (Aerobic Mineralisation in Surface Water - Simulation Biodegradation Test)

GLP compliance:

yes

Specific details on test material used for the study:

Radiochemical purity 98.8%

Radiolabelling:

yes

Remarks:

See test material information

Oxygen conditions:

aerobic

Inoculum or test system:

natural water: freshwater

Details on source and properties of surface water:

River water will be freshly sampled from a source known not to be contaminated with plant protection products or subject to discharges of effluents. The pH, oxygen concentration, redox potential and temperature of the water will be measured at the collection site together with information on sampling, depth and appearance of water sample. During transport the water should not exceed the temperature of the test.

Duration of test (contact time):

0 - <= 90 d

Parameter followed for biodegradation estimation:

CO2 evolution

other: Chromatographic analysis

Details on study design:

Study in progress

Reference substance:

other: Benzoic acid [14C(U)]

Remarks on result:

other: Study planned and commissioned. Expected completion and results August 2021

Compartment:

natural water: freshwater

Remarks on result:

other: Study planned and commissioned. Expected completion and results August 2021

Other kinetic parameters:

other:

Transformation products:

no

Details on transformation products:

Study planned and commissioned. draft study report received November 2021

Details on results:

Study planned and commissioned. Expected completion August 2021 draft report November 2021

Results with reference substance:

Study planned and commissioned. Expected completion August 2021 draft report November 2021

Executive summary:

4,4-isopropylidenediphenol, ethoxylated (BPA-4EO) is being assessed for the purpose of the evaluation of biodegradation in water.  The study, according to OECD 309, has been planned and commissioned to Innovative Environmental services (IES) Limited, Benkenstrasse 260, 4108 Witterswil, Switzerland.  A draft study report has been received (November 2021) and is currently under reviewed and work is progressing to identify the degradation products observed.  

Description of key information

4,4-isopropylidenediphenol, ethoxylated (BPA-4EO) is being assessed for the purpose of the evaluation of biodegradation in water.  The study, according to OECD 309, has been planned and commissioned to Innovative Environmental services (IES) Limited, Benkenstrasse 260, 4108 Witterswil, Switzerland.

Receipt of the draft study from the CRO is expected on November 2021.

Concerning the biodegradation in sediment, according to column 2 of Annexes IX and X, further testing on biodegradation should be considered if the chemical safety assessment indicates the need to investigate further the degradation of the substance and its degradation products. Based on the screening study conducted with BPA (1-4.5 EO) it was concluded that the substance is not readily biodegradable but can be concluded to be inherently biodegradable. Furthermore the results from the CSA do not trigger a need for further investigation of biotic degradation as risk for the sediment compartment are acceptable in every scenario (RCR < 1). With respect to PBT/vPvB properties the substance is not considered PBT/vPvB and therefore further testing on biodegradation is not triggered. In accordance with column 2 of Annexes IX and X, no further biodegradation testing in sediment are needed.