Registration Dossier
Registration Dossier
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EC number: 205-999-9 | CAS number: 280-57-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study pre-dates GLPs Purity was not documented. Clinical signs were not reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,4-diazabicyclooctane
- EC Number:
- 205-999-9
- EC Name:
- 1,4-diazabicyclooctane
- Cas Number:
- 280-57-9
- Molecular formula:
- C6H12N2
- IUPAC Name:
- 1,4-diazabicyclooctane
- Details on test material:
- Dabco Crystalline Catalyst
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Concentration in vehicle: 25% weight to volume
- Doses:
- 250, 500, 1000, 2000, and 4000 mg/kg (active ingredient)
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 700 mg/kg bw
- 95% CL:
- > 500 - < 1 100
- Mortality:
- At 250 mg/kg, no rats died. At 500 mg/kg, one rat died. At 1000 mg/kg four rats died. At greater than or equal to 2000 mg/kg all of the rats died. The deaths occurred in three days or less.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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