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Diss Factsheets
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EC number: 233-297-2 | CAS number: 10108-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1990 (no other information available)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- The test is presented in a short summary. However, the information necessary for the assessment are given, and the test conditions are in accordance with US guideline.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicological evaluation of cerium nitrate
- Author:
- Lambert CE, Barnum EC, Shapiro R
- Year:
- 1 993
- Bibliographic source:
- J Am Coll Toxicol, 12(6), 615
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: similar to EPA OPPTS 870.2400 (Acute eye irritation)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cerium nitrate, hexahydrate
- IUPAC Name:
- Cerium nitrate, hexahydrate
- Test material form:
- not specified
- Details on test material:
- - Test material identity: Cerium nitrate (CAS No. 10294-41-4), as cerium (III) nitrate hexahydrate
- Analytical purity: No data
- Impurities: No data
- Lot/batch no.: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS:
- Source, Age at study initiation, Weight at study initiation, Housing, Diet, Water, Acclimation period: data not available
ENVIRONMENTAL CONDITIONS:
- Temperature, Humidity, Air changes, Photoperiod: data not available
IN-LIFE DATES: data not available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the right eye of each rabbit was untreated
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 g - Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- - Removal of test system: 3 of the treated eyes were rinsed with saline 30 seconds post-instillation
- Scoring system: according to the method of Draize
- Tool used to assess score: data not available
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: draize scores
- Basis:
- mean
- Time point:
- other: 24-48-72 hours
- Score:
- 41 - 42.3
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- other: Unwashed eyes (3 rabbit mean): 41.0 (24h), 42.3 (48h), 42.3 (72h)
- Irritation parameter:
- other: draize scores
- Basis:
- mean
- Time point:
- other: 24-48-72 hours
- Score:
- 18 - 23
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- other: Washed eyes (3 rabbit mean): 23.0 (24h), 21.3 (48h), 18.0 (72h)
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Classification: risk of serious damage to eyes;
In this study, cerium nitrate was found to be severely and moderately irritating to unwashed and washed eyes respectively. - Executive summary:
In a primary eye irritation study (Lambert CE, 1993), 0.1 g of cerium nitrate (purity unknown) was instilled into the left eye of New Zealand Albino rabbits (6 animals). 3 treated eyes were rinsed after 30 seconds. Animals then were observed for 3 days. Irritation was scored by the method of Draize. In this study, cerium nitrate was found severely irritating to the eye of rabbit.
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