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EC number: 219-854-2 | CAS number: 2551-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
The Functional Observational Battery (FOB) tests and spontaneous motor activity tests, performed as a part of a GLP-compliant 28-days repeated dose inhalation toxicity study with reproductive and developmental screening, revealed no effects in rats exposed to 302687 mg/m3 SF6 6h/day for at least 28 days. The substance is considered to be not neurotoxic.
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 302 687 mg/m³
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The neurotoxic potential of sulphur hexafluoride was evaluated in a 28-days repeated dose toxicity inhalation study with reproductive and developmental toxicity screening, performed under GLP and according to OECD Guideline 422 (TNO, 2009). Groups of 12 male and female Wistar rats were exposed to a limit (analytical) concentration of 302687 mg/m3 (target concentration of 50000 ppm) SF6 and air (control group) for 6
hours/day daily. Males were exposed for at least 2 weeks prior to mating, during mating and after the mating period at least until the minimum total exposure period of 28 days has been completed, while females were exposed for at least 2 weeks prior to mating, during mating and up to gestation day 19. Functional Observational Battery (FOB) tests, including an assessment of grip strength and sensory reactivity to stimuli of different types, and spontaneous motor activity measurements were performed in 5 males/group prior to the end of dosing and 5 females/group prior to day 4 of lactation. Males were sacrificed after 29 days of exposure; females at day 4 of lactation or shortly after.No mortalities were noted. No adverse changes which were considered to be related to treatment were noted with respect to body weight, food consumption, gross pathology, clinical chemistry, haematological and histopathological examinations. Weekly detailed clinical observations outside the home cage did not indicate an effect. A statistically significant decrease of the landing footsplay and a statistically significant increase of the motor activity were observed in male animals of the SF6-exposed group in comparison to controls. Those findings were considered incidental and are most probably due to the atypical (high) control values and did not reveal an effect when compared to the historical range. Furthermore, no other differences in neurobehavioural testing were observed between the control and the SF6-exposed group.
Based on these results, the NOAEC for neurotoxic effects was set at 302687 mg/m3.
Justification for classification or non-classification
Based on the lack of neurotoxic effects in a GLP-compliant 28-days inhalation toxicity study with reproductive and developmental toxicity screening, classification is not warranted in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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