Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-943-5 | CAS number: 101-43-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Monomeric methyl methacrylate studies on toxicity
- Author:
- Spealman C.R., Main R.J., Haag H.B., Larson P.S.
- Year:
- 1 945
- Bibliographic source:
- Ind. Med. 14: 292-298
Materials and methods
- Principles of method if other than guideline:
- Study to assess the acute inhalative toxicity in mice.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Methyl methacrylate
- EC Number:
- 201-297-1
- EC Name:
- Methyl methacrylate
- Cas Number:
- 80-62-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- methyl methacrylate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 3 h
Results and discussion
Effect levelsopen allclose all
- Key result
- Dose descriptor:
- LC50
- Effect level:
- 55 mg/L air
- Exp. duration:
- 3 h
- Remarks on result:
- other: 55.0 mg/L equals 13220 ppm
- Dose descriptor:
- LC100
- Effect level:
- 61.8 mg/L air
- Exp. duration:
- 3 h
- Remarks on result:
- other: 61.8 mg/L equals 14860 ppm
- Dose descriptor:
- other: LC5
- Effect level:
- 26.2 mg/L air
- Exp. duration:
- 3 h
- Remarks on result:
- other: 26.2 mg/L equals 6300 ppm
- Dose descriptor:
- other: LC13
- Effect level:
- 47.7 mg/L air
- Exp. duration:
- 3 h
- Remarks on result:
- other: 47.7 mg/L equals 11470 ppm
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
