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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No data on purity, different number of rabbits/group.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Guideline:
other:
Principles of method if other than guideline:
4 dose groups: 126 mg/kg (1 male), 200 mg/kg (2 males and 3 females), 316 mg/kg (1 female), 501 mg/kg (1 male); 24-h exposure; TS undiluted; post application observation period: 14 days, record of signs of intox., gross autopsy
GLP compliance:
not specified
Test type:
other:
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dicyclohexylamine
EC Number:
202-980-7
EC Name:
Dicyclohexylamine
Cas Number:
101-83-7
Molecular formula:
C12H23N
IUPAC Name:
N-cyclohexylcyclohexanamine

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
4 dose groups: 126 mg/kg (1 male), 200 mg/kg (2 males and 3 females), 316 mg/kg (1 female), 501 mg/kg (1 male); 24-h exposure;
Duration of exposure:
24h
Doses:
126, 200, 316, 501
No. of animals per sex per dose:
4 dose groups: 126 mg/kg (1 male), 200 mg/kg (2 males and 3 females), 316 mg/kg (1 female), 501 mg/kg (1 male); 24-h exposure;
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
200 - 316 mg/kg bw
Mortality:
time of mortality: within 16 hours
Clinical signs:
other: reduced appetite and activity (2-3 days in survivors), increasing weakness, collapse, and death
Gross pathology:
dead animals 0 hemorrhagic areas of the lungs, liver discoloration, enlarged gall bladder, and gastrointestinal inflammation
survivors: viscera appeared normal

Any other information on results incl. tables

dosage    initial weight (kg)      Mortality
mg/kg       male  female         male  female

126        2.0             -             0/1     -
200        2.0            2.4          1/2    0/3
316         -             2.1             -     1/1
501        2.1             -             1/1     -

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 200 - 316 mg/kg bw.
Executive summary:

LD50: 200-316 mg/kg bw (male/female), reduced apetite and activity repoerted for survivors.