Registration Dossier
Registration Dossier
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EC number: 202-980-7 | CAS number: 101-83-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No data on putiry of TS, no data on GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 6 male Sprague-Dawley Albino rats were exposed to dicyclohexylamine vapor; concentration: 1.4 mg/l
Chamber temperature: 27 degree C
Chamber humidity: 80 %
Chamber volume: 35 l
Air flow rate: 4.0 l/min
Vaporized sample: 2.1 g
Record of signs of intoxication, gross autopsy - GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Dicyclohexylamine
- EC Number:
- 202-980-7
- EC Name:
- Dicyclohexylamine
- Cas Number:
- 101-83-7
- Molecular formula:
- C12H23N
- IUPAC Name:
- N-cyclohexylcyclohexanamine
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- dicyclohexylamine vapor;
concentration: 1.4 mg/l
Chamber temperature: 27 degree C
Chamber humidity: 80 %
Chamber volume: 35 l
Air flow rate: 4.0 l/min
Vaporized sample: 2.1 g - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- concentration: 1.4 mg/l
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 1.4 mg/L air
- Based on:
- not specified
- Exp. duration:
- 6 h
- Mortality:
- Mortality: 0/6
- Clinical signs:
- other: slight lethargy during exposure; no toxic signs following exposure
- Body weight:
- no data
- Gross pathology:
- none reported
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LC50> 1.4 mg/l
- Executive summary:
LC50> 1.4 mg/l, no deaths occured, no gross pathology recorded, slight lethargy was reported during exposure; with no toxic signs following exposure
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