Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: Expert Statement
Adequacy of study:
key study
Reliability:
other: Expert Statement
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
In order to fulfil the requirements for submission of a REACH dossier according to Annex IX of REACH Regulation (EC) No.1907/2006 (for substances >100 tones/year) and in absence of data on the toxicokinetics and dermal absorption, an assessment of toxicological behaviour is required. No studies are available on the toxicokinetics, metabolism and distribution of 1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate.

Data source

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
While toxicokinetic data is not available on 1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate, if absorbed, it is expected to breakdown rapidly. There is no information on the actual breakdown products formed. 1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate is not expected to bioaccumulate.
Executive summary:

The available physico-chemical and toxicological information of the substance has been evaluated and used to assess the toxicological behaviour. The results of this analysis will address the question on how the chemical will react in the body.

The ECHA “Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance May 2008” document provides guidance, which physico-chemical properties commonly determine oral, inhalatory and dermal absorption, distribution, metabolism and elimination of substance.