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Long-term toxicity to aquatic invertebrates

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Description of key information

A study has been performed to assess the chronic toxicity to aquatic invertebrate. In the key study (OECD 211 GLP), no toxicity was observed at a loading concentration of 10 mg/L.

Key value for chemical safety assessment

Additional information

A GLP study (Kean, et al. 2015) investigated the chronic toxicity of 1,1,3,3-tetramethylbutyl peroxy2-ethyl hexanoate (CAS 22288-43-3) and its degradation products to Daphnia magna in a 21 day reproduction test under semi-static conditions.

Due to the low water solubility of the substance a WAF was prepared as described in the RSS. The test substance at its maximum achievable concentration in test medium and the accumulated degradation products resulting from a loading concentration of 10 mg/L degraded for 6 days did not have any detectable effects on the reproduction or dry weight or length of Daphnia magna in a 21 day chronic study under semi static conditions. It can be concluded that the water soluble degradation products as well as the parent material are not likely to display any chronic toxicity at the concentrations achievable in the environment.

This is supported by the estimated and measured data available on chronic toxicity to crustaceans for the degradation products:

Substance

Test data
[mg/L]

ECOSAR [mg/L]

2 -ethylhexanoic acid

18-25

12.6

Neopentyl alcohol

-

15.3

Acetone

>=79

123