Registration Dossier

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
of read across substance
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two toxicity study of microorganism for the test chemical :
1) Toxicity of test chemical were studied based on the effect observed on microorganisms.
2) Study was conducted to evaluate the effect of test chemical on the Proliferation ratio of Tetrahymena pyriformis (Ciliate).
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Tetrahymena pyriformis
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Reference substance (positive control):
not specified
Duration:
48 h
Dose descriptor:
IC50
Effect conc.:
17 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Duration:
60 h
Dose descriptor:
EC50
Effect conc.:
66.34 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Validity criteria fulfilled:
not specified
Conclusions:
The effect concentration of test material on Tetrahymena pyriformis (Ciliate) was observed to be in the range of 17-66.34 mg/l
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of test material on microorganism .The studies are as mentioned below:

Toxicity of test chemical were studied based on the effect observed on microorganisms. The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect was determined to be 17 mg/L.

In another study of functionally similar read across substance study was conducted to evaluate the effect of test chemical on the Proliferation ratio of Tetrahymena pyriformis (Ciliate). Test conducted under the static system for 60 hrs. Based on the inhibition of proliferation rate of test organism Tetrahymena pyriformis (Ciliate) by the chemical exposure for 60 hrs, the EC50 was determine to be 66.34 mg/l.The effect concentration of test material on Tetrahymena pyriformis (Ciliate) was observed to be in the range of 17-66.34 mg/l

Description of key information

Toxicity to microorganism:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of test material on microorganism .The studies are as mentioned below:

Toxicity of test chemical were studied based on the effect observed on microorganisms. The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect was determined to be 17 mg/L.

In another study of functionally similar read across substance study was conducted to evaluate the effect of test chemical on the Proliferation ratio of Tetrahymena pyriformis (Ciliate). Test conducted under the static system for 60 hrs. Based on the inhibition of proliferation rate of test organism Tetrahymena pyriformis (Ciliate) by the chemical exposure for 60 hrs, the EC50 was determine to be 66.34 mg/l.The effect concentration of test material on Tetrahymena pyriformis (Ciliate) was observed to be in the range of 17-66.34 mg/l

Key value for chemical safety assessment

EC50 for microorganisms:
17 mg/L

Additional information

Toxicity to microorganism:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of test material on microorganism .The studies are as mentioned below:

Toxicity of test chemical were studied based on the effect observed on microorganisms. The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect was determined to be 17 mg/L.

In another study of functionally similar read across substance study was conducted to evaluate the effect of test chemical on the Proliferation ratio of Tetrahymena pyriformis (Ciliate). Test conducted under the static system for 60 hrs. Based on the inhibition of proliferation rate of test organism Tetrahymena pyriformis (Ciliate) by the chemical exposure for 60 hrs, the EC50 was determine to be 66.34 mg/l.The effect concentration of test material on Tetrahymena pyriformis (Ciliate) was observed to be in the range of 17-66.34 mg/l