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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23.03.2013 - 09.04.2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to
Guideline:
other: Gravimetric method
Principles of method if other than guideline:
Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material : 5-methoxy-1,3-dihydro-2H-benzimidazole-2-thione
- Molecular formula : C8H8N2OS
- Molecular weight : 180.2302 g/mol
- Smiles notation : COc1ccc2c(c1)nc([nH]2)S
- InChl : 1S/C8H8N2OS/c1-11-5-2-3-6-7(4-5)10-8(12)9-6/h2-4H,1H3,(H2,9,10,12)
- Substance type : Organic
- Physical state : Solid
Key result
Medium:
methanol
Solubility:
4 100 mg/L
Temp.:
37 °C
Remarks on result:
other: No other detail available
Key result
Medium:
other: Petroleum
Solubility:
50 mg/L
Temp.:
37 °C
Remarks on result:
other: No other detail available
Conclusions:
Based on the gravimetric method, the experimental value of solubility of test chemical in methanol at temperature of 37 Deg C was determine to be 4100 mg/L indicating that test chemical is soluble in methanol. Similarly experimental value of solubility in Petroleum ether at temperature of 37 Deg C was determine to be 50 mg/L indicating that test chemical is slightly soluble in Petroleum ether.
Executive summary:

Based on the gravimetric method, the experimental value of solubility of test chemical in methanol at temperature of 37 Deg C was determine to be 4100 mg/L indicating that test chemical is soluble in methanol. Similarly experimental value of solubility in Petroleum ether at temperature of 37 Deg C was determine to be 50 mg/L indicating that test chemical is slightly soluble in Petroleum ether.

Description of key information

Based on the gravimetric method, the experimental value of solubility of test chemical in methanol at temperature of 37 Deg C was determine to be 4100 mg/L indicating that test chemical is soluble in methanol. Similarly experimental value of solubility in Petroleum ether at temperature of 37 Deg C was determine to be 50 mg/L indicating that test chemical is slightly soluble in Petroleum ether.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
2 216 mg/L

Additional information

Based on the gravimetric method, the experimental value of solubility of test chemical in methanol at temperature of 37 Deg C was determine to be 4100 mg/L indicating that test chemical is soluble in methanol. Similarly experimental value of solubility in Petroleum ether at temperature of 37 Deg C was determine to be 50 mg/L indicating that test chemical is slightly soluble in Petroleum ether.