Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

6 -Chlor-Chlormethyldien (ZK 10882) was examined for mutagenic activity up to 500 µg/plate in the five histidine-dependent Salmonella typhimurium strains TA 1535, TA 100, TA 1537, TA 1538 and TA 98 with and without metabolic activation. No cytotoxic effect was observed up to 0.5 mg/plate with and without S9 mix. There were visible precipitates in the agar from 0.05 mg/plate onwards with and without S9 mix in all tested strains.

There was no evidence for a mutagenic activity of 6 -Chlor-Chlormethyldien, when tested up to the precipitating dose level of 0.5 mg/plate in the absence and presence of S9 mix.

Short description of key information:
Gene mutation (bacterial reverse mutation assay, equivalent to OECD TG471): negative with and without metabolic activation
[Schering AG, Report No. X093 -draft-, 1996-07-30]

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the results there is no classification required according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP).