Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The study contains no details on test substance source, purity, composition, batch number or storage conditions. Although test results are reported there are significant deficiencies in experimental details such as the method of atmosphere generation.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1988
Report Date:
1992

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
200-300g
placed into a sealed 120-L chamber containing sample vapour (near saturation)

Administration / exposure

Route of administration:
other: not specified
Type of inhalation exposure:
whole body
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
6 h
Details on study design:
14 day observation period

Results and discussion

Mortality:
no deaths
Clinical signs:
no signs
Gross pathology:
no gross legions

Applicant's summary and conclusion