Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

For the substance no indication was found for a potential of skin or eye irritation/corrosion in validated in vitro tests (OECD 431; OECD 439) or in an in vitro eye irritation test (HET-CAM) according to a testing protocol recommended by ICCVAM (ICVAM Test Method Evaluation Report, 2006).

In vivo, the test substance showed slight effects on rabbit skin (OECD TG 404; erythema scores 1 or 2, fully reversible after 7 days at the latest) and also slight effects on the eyes of rabbits (OECD TG 405; conjunctivae scores 1, fully reversible after 72 hours at the latest). There were no systemic intolerance reactions observed in the two in vivo studies.

For respiratory irritation a subacute (28-days) repeated inhalation toxicity study (see chapter repeated dose toxicity) revealed respiratory irritation at concentrations of 25.8 mg/m³ and above. This was based on histopathology findings and on bronchoalveolar lavage analysis.


Justification for classification or non-classification

According to Regulation (EC) No 1272/2008, Annex I no classification is warranted for skin or eye irritation/corrosion.

According to Regulation (EC) No 1272/2008, Annex I, the substance has to be classified as STOT SE 3 (H335: May cause respiratory irritation).