Registration Dossier
Registration Dossier
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EC number: 272-238-5 | CAS number: 68784-31-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts
- EC Number:
- 272-238-5
- EC Name:
- Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts
- Cas Number:
- 68784-31-6
- Molecular formula:
- C(16-24) H(36-42) O4 P2 S4 Zn
- IUPAC Name:
- Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: 2.346 to 2.608 kg
- Weight at study initiation:
- Housing: Individually in wire mesh suspension cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17.8-26.1
- Humidity (%): 40-70
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12 hours
IN-LIFE DATES: From: To:
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution):
VEHICLE
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Lot/batch no. (if required):
- Purity: - Number of animals or in vitro replicates:
- 6 (non rinsed) and 3 (rinsed)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsing with 200 ml of lukewarm tap water was done on 3 of 9 animals
- Time after start of exposure: 30 seconds
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: Fluorescein sodium ophthalmic solution U.S.P. followed by UV illumination
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 1.67
- Reversibility:
- not reversible
- Remarks on result:
- other: Non-rinsed
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 1.22
- Reversibility:
- fully reversible
- Remarks on result:
- other: Rinsed
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 1
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: Non-rinsed
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 0.22
- Reversibility:
- fully reversible
- Remarks on result:
- other: Rinsed
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 2.22
- Reversibility:
- not reversible
- Remarks on result:
- other: Non-rinsed
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other: Rinsed
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 2.78
- Reversibility:
- not reversible
- Remarks on result:
- other: Non-rinsed
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 2.11
- Reversibility:
- fully reversible
- Remarks on result:
- other: Rinsed
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
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