Registration Dossier
Registration Dossier
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EC number: 232-136-3 | CAS number: 7787-93-1
Endpoint summary
Administrative data
Description of key information
In a well conducted Buehler skin sensitisation test (Hűls AG, 1998), dichloro(3-chloropropyl)methylsilane gave no evidence of sensitising potential in guinea pigs challenged at 1% in corn oil following induction with 2.5% in the same vehicle. The selected study is the only available skin sensitisation study for the registered substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The study summarised is the only study available for skin sensitisation. The induction and challenge concentrations were consistent with the requirements of OECD 406 in relation to their irritant status; 1% in corn oil being non-irritant and 2.5% in this vehicle a mild-moderate irritant.
Dichloro(3-chloropropyl)methylsilane hydrolyses rapidly in contact with water and moist air, releasing two moles of hydrogen chloride for each mole of parent material. It is therefore classified as corrosive and sensitisation testing under conditions where its corrosive properties pertained would not be appropriate.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data do not support the classification of dichloro(3-chloropropyl)methylsilane for sensitisation according to Regulation (EC) No 1272/2008.
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