Registration Dossier
Registration Dossier
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EC number: 203-828-2 | CAS number: 111-05-7
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and according to standard guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-(2-hydroxypropyl)oleamide
- EC Number:
- 203-828-2
- EC Name:
- N-(2-hydroxypropyl)oleamide
- Cas Number:
- 111-05-7
- Molecular formula:
- C21H41NO2
- IUPAC Name:
- N-(2-hydroxypropyl)oleamide
Constituent 1
Results and discussion
- Dissociating properties:
- no
Dissociation constant
- Remarks on result:
- other: No equivalence points within the pH versus the titrant solutions
Any other information on results incl. tables
A solution of the test substance was prepared using 3.3176g of the test substance in 1000ml of ultrapure water exempted of CO2, resulting in a solution of 0.01 mol/l. The solution was equilibrated at 20 +/- 1°C and the titration was done measuring the pH after each addition of the titrant solution (NaOH 0.1 mol/l). After that process, a graph of the titrant volume against the pH measurement was plotted. Thereafter the pKa of the test substance was obtained by the correspondent pH of half the volume of the equivalence point.
The same procedure was done using the 0.1 mol/l solution of HCl as a titrant.
Applicant's summary and conclusion
- Conclusions:
- The test substance does not dissociate under the conditions of the test
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