Registration Dossier
Registration Dossier
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EC number: 202-046-9 | CAS number: 91-17-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949-1951
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study briefly summarised, meets generally accepted scientific principles, acceptable for assessment. Restrictions: Only male animals used, no guideline, no GLP
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: list IV
- Author:
- Smyth HF Jr, Carpenter CP and Weil CS
- Year:
- 1 951
- Bibliographic source:
- Arch. Ind. Hyg. Occup. Med. 4, 119-122
Materials and methods
- Principles of method if other than guideline:
- Smyth HF Jr, Carpenter CP (1944): The place of the range finding test in the industrial toxicology laboratory. J. Ind. Hyg. Toxicol. 26, 269-273 and subsequent updates
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Decahydronaphthalene
- EC Number:
- 202-046-9
- EC Name:
- Decahydronaphthalene
- Cas Number:
- 91-17-8
- Molecular formula:
- C10H18
- IUPAC Name:
- decahydronaphthalene
- Details on test material:
- decahydronaphthalene, no data on purity
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- - Area covered: clipped trunk
- Occlusion: impervious flexible film ("vinylite" sheeting)
- Exposure period: 24 hours
- Observation period: 14 days - Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Statistics:
- Thompson, W.R. (1947): Use of moving averages and interpolation to estimate median effective dose. Bact. Rev. 11, 115
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 200 mg/kg bw
- 95% CL:
- 3 380 - 8 000
- Mortality:
- LD50 = 5.9 (3.84-9.06) mL/kg bw
=5200 (3380-8000) mg/kg bw - Clinical signs:
- other:
Applicant's summary and conclusion
- Conclusions:
- The LD50 (rabbit) for decahydronaphthalene applied to the skin of the rabbit is 5.9 mL/kg bw (=5.2 g/kg bw). Thus decahydronaphthalene showed low acute toxicity in rabbits after dermal application.
- Executive summary:
The LD50 for decahydronaphthalene applied undiluted to the clipped skin of the rabbit trunk under "Vinylit" sheeting for 24h was 5.9 mL/kg bw (95% confidence limit 3.84-9.06). This corresponded to 5200 (3380-8000) mg/kg bw.
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