Registration Dossier
Registration Dossier
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EC number: 238-270-9 | CAS number: 14324-55-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Predates GLP and OECD guidelines, minor restrictions, available as unpublished report
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- No method guideline specified
- GLP compliance:
- no
- Type of study:
- patch test
Test material
- Reference substance name:
- Zinc bis(diethyldithiocarbamate)
- EC Number:
- 238-270-9
- EC Name:
- Zinc bis(diethyldithiocarbamate)
- Cas Number:
- 14324-55-1
- Molecular formula:
- C10H20N2S4Zn
- IUPAC Name:
- zinc bis(diethyldithiocarbamate)
- Details on test material:
- Name of test material (as cited in study report): Ethasan
Constituent 1
In vivo test system
Test animals
- Species:
- human
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Dimethylphtalate
- Concentration / amount:
- Tested as 50% w/v in Dimethylphtalate
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Dimethylphtalate
- Concentration / amount:
- Tested as 50% w/v in Dimethylphtalate
- No. of animals per dose:
- 50 human volunteers
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: Skin changes accompanying application No. 1 through 15
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 1
- Total no. in group:
- 50
- Clinical observations:
- Slight erythema
- Reading:
- other: Challenge
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 0
- Total no. in group:
- 50
Applicant's summary and conclusion
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