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EC number: 238-270-9 | CAS number: 14324-55-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Comparable to guideline study, predates GLP, very limited reporting, but acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- Single dose of 2000 mg/kg bw of the test substance was applied to pre-moistened hair-clipped skin of each of the 6 rabbits under occlusive dressing. The patch was removed 24 hours post-dosing and animals were observed for 7 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Zinc bis(diethyldithiocarbamate)
- EC Number:
- 238-270-9
- EC Name:
- Zinc bis(diethyldithiocarbamate)
- Cas Number:
- 14324-55-1
- Molecular formula:
- C10H20N2S4Zn
- IUPAC Name:
- zinc bis(diethyldithiocarbamate)
- Details on test material:
- - Name of test material (as cited in study report): Ethyl Ziram (WTR 38)
- Physical state: White powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk
- Type of wrap if used: Covered with a two-ply layer of wet gauze and overcovered with an empervious sleeve. - Duration of exposure:
- 24 hours
- Doses:
- Single dose: 2000 mg/kg
- No. of animals per sex per dose:
- 6 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None.
- Clinical signs:
- other: other: All animals remaind asymptomatic during the observation period.
- Gross pathology:
- No data.
Applicant's summary and conclusion
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