Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was carried out in compliance with the Directive 92/69/EEC, Part A.8 "Partition coefficient", 1992.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report Date:
2000

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
Swiss Federal Department of the Interior
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Name of test material (as cited in study report): Triol
- Physical state: white solid
- Analytical purity: 99.5 % (LC), 99.8 % (DSC)
- Lot/batch No.: 6262/ZTN/03/N/08/001/003
- Expiration date of the lot/batch: 1 December 2000
- Stability under test conditions: not specified in water
- Storage condition of test material: in refridgerator at 4 +/- 3 °C, protected from sunlight
- Other:

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
0.5

Any other information on results incl. tables

Determination of the partition coefficient (n-Octanol/water) of Triol.

Number of anlyses

Mean retention time (min)

k

log k

log Pow

Formamide

2

2.15

-

-

-

Reference substances

4-Acetylpyridine

6

3.87

0.80

-0.10

0.5

Acetanilide

6

4.37

1.03

0.01

1.0

Benzonitrile

6

10.87

4.06

0.61

1.6

Nitrobenzene

6

15.58

6.25

0.80

1.9

Anisole

6

19.86

8.24

0.92

2.1

Toluole

6

41.95

18.51

1.27

2.7

Test article

3

3.50

0.63

-0.20

0.5

Linear regression

slope =

y-axis intercept =

coefficient of regression =

0.666

-0.504

0.989

Applicant's summary and conclusion

Conclusions:
The partition coefficient (n-Octanol/water) of Triol was determined to be: log Pow = 0.5, using the HPLC method.
Executive summary:

The determination of the partition coefficient (n-Octanol/water) of Triol was performed according to the Directive 92/69/EEC, Part A.8, 1992, and the OECD Guideline No. 117, using the HPLC method.

Six standard solutions were selected exhibiting a range of log Pow values between 0.5 and 2.7.

The test item solution was injected three times and the reference solutions were injected six times. The log Pow was calculated using a regression curve (log k' vs. log Pow) and was found to be 0.5.