2-ethyl-4-methylimidazole

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Method: BASF-Test: Test was performed in principle as described in OECD Guideline 403. The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20°C). 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder for 8h. The documentation of clinical signs was performed over a period of 7 days. In order to verify the results, the test was repeated once.

GLP compliance:

no

Test type:

other: Inhalation-risk test (IRT)

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethyl-4-methylimidazole

EC Number:

213-234-5

EC Name:

2-ethyl-4-methylimidazole

Cas Number:

931-36-2

Molecular formula:

C6H10N2

IUPAC Name:

2-ethyl-4-methyl-1H-imidazole

Details on test material:

- Name of test material (as cited in study report): 2-ethyl-4-methylimidazol
- Physical state: solid

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

Concentrations:

Saturated vapour at 20°C (0.03 mg/L)

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7days
- Frequency of observations and weighing: observations: daily; weighing: at the beginning and end of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight (group only, no single animal weights)

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

discriminating conc.

Effect level:

0.03 other: Saturated vapour at 20 ºC

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: none of the animals died

Effect levels 2

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 0.03 mg/L air

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: theoretical value, calculated based on vapour pressure

Mortality:

No mortality occurred.

Clinical signs:

other: distinct mucous membrane irritation

Body weight:

No data.

Gross pathology:

No treatment related findings.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met