Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
Reaction mass of (1RS)-1-[(1RS)-3,3-dimethylcyclohexyl]ethyl [(2RS,3RS)-3-ethyloxiran-2-yl]acetate and (1RS)-1-[(1RS)-3,3-dimethylcyclohexyl]ethyl [(2SR,3SR)-3-ethyloxiran-2-yl]acetate and (1RS)-1-[(1SR)-3,3-dimethylcyclohexyl]ethyl [(2RS,3RS)-3-ethyloxiran-2-yl]acetate and (1RS)-1-[(1SR)-3,3-dimethylcyclohexyl]ethyl [(2SR,3SR)-3-ethyloxiran-2-yl]acetate
EC number: 950-412-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5-05-2014 to 13-05-2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study performed under GLP. All relevant validity criteria were met.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected: June 2013; signature: November 2013
- Type of method:
- flask method
- Water solubility:
- 13.2 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 96 h
- Temp.:
- 20 °C
- pH:
- 8
- Remarks on result:
- other: mean of 24, 48 and 72 h in duplicate measurements tested after 96 hours incubation; (n =6)
- Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
The test item water solubility was determined to be 13.2 mg/L at pH 8.0 and 20.0 °C. - Executive summary:
The water solubility of the substance was determined according to OECD Method 105 and EU Method A.6 in accordance with GLP. Determinations with preincubation at 30 ± 0.5 °C and stirring rate of 300 rpm for 24, 48 and 72 hours respectively. After preincubation the temperature was deuced to the test temperature of 20 ± 0.5 °C for 24 h and secondary for 96 h with stirring at approx. 100 rpm. The analytical method (SPME-GC-MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. Temperatures were kept constant within ± 0.5 °C. The determined solubilities of the two test vessels difference by more than 15 %, however this was deemed acceptable see below. The analytical method (SPME-GC-MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility was determined 24 and 96 h after reduction to test temperature (20°C). The results obtained for the first measurement (24 h after reduction to test temperature) were slightly outside the calibration range and therefore only used for comparison. A plateau phase was reached. The second set of samples (96 h after reduction to test temperature) gave more scattering results, but as they are comparable to the first measurement they were used to calculate the water solubility. The concentrations, measured for the two longest pre-incubation times (48 and 72 h) of the sampling after 96 h of incubation, differed for 22%. This deviation was considered to be negligible, as the results obtained from an additional sampling (results slightly out of calibration range, therefore not used for evaluation) after 24 h of incubation showed comparable and less differing (7%) results, proving that plateau phase was reached. The water solubility of each isomer contributing to the purity of the test item was determined to be 10.6 mg/L. The water solubility was also determined for the test item as a whole. Under the conditions of this study, the mean water solubility of the substance was determined to be 13.2 mg/L at 20 ± 0.5 °and pH 8.0.
Reference
Preliminary test:
A non-GLP preliminary test has been performed to determine the application dose used in the definitive study. For this purpose, 3 replicates of a water: test item mixture at an application dose of approx. 1 g/L were mixed overnight (approx. 24 h) and the aqueous phase was centrifuged (10 m in at 10000 x g and 20 °C) analysed via GC-MS.Due to the application procedure, instead of the fivefold 100 µL of the test item were transferred directly as layer onto 100 mL double distilled water. The determined solubility was in the range of 7 mg/L.
Definitive test:
The solubility of the test item in double distilled water was determined employing the flask method at 20 ± 0.5 °C with preincubation at 30 ± 0.5 °C. The water solubility was respectively at pH 8.0:
Table 1. Water solubility (96 h incubation – measured after 96 h at 20 ± 0.5 °C)
Preincubation time / hours |
Replicate |
Measured concentration #1 / mg/L |
Mean / mg/L |
24 |
1 |
10.3 |
|
|
2 |
22.0 |
16.2 |
48 |
1 |
13.5 |
|
|
2 |
15.5 |
14.5 |
72 |
1 |
12.0 |
|
|
2 |
11.8 |
11.9 |
|
|
|
|
Mean (48 – 72 h) |
|
|
13.2 |
Deviation / % #2 |
|
|
22.0 |
CV / % #3 |
|
|
13.4 |
|
|
|
|
#1 Mean value of triplicate samples, single injected, dilution factor 500
#2 Calculated
#3 Coefficient of variation after 48- 72 h preincubation
Temperatures were kept constant within ± 0.5 °C. The determined solubilities of the two test vessels difference by more than 15 %, however this was deemed acceptable see below. The analytical method (SPME-GC-MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility was determined 24 and 96 h after reduction to test temperature (20°C). The results obtained for the first measurement (24 h after reduction to test temperature) were slightly outside the calibration range and therefore only used for comparison. A plateau phase was reached. The second set of samples (96 h after reduction to test temperature) gave more scattering results, but as they are comparable to the first measurement they were used to calculate the water solubility. The concentrations, measured for the two longest pre-incubation times (48 and 72 h) of the sampling after 96 h of incubation, differed for 22%. This deviation was considered to be negligible, as the results obtained from an additional sampling (results slightly out of calibration range, therefore not used for evaluation) after 24 h of incubation showed comparable and less differing (7%) results, proving that plateau phase was reached.
Description of key information
Water Solubility: 13.2 mg/L at pH 8.0 and 20 °C, flask method - OECD TG 105, 2016
Key value for chemical safety assessment
- Water solubility:
- 13.2 mg/L
- at the temperature of:
- 20 °C
Additional information
Key study : OECD TG 105, 2016 : The water solubility of the substance was determined according to OECD Method 105 and EU Method A.6 in accordance with GLP. Determinations with preincubation at 30 ± 0.5 °C and stirring rate of 300 rpm for 24, 48 and 72 hours respectively. After preincubation the temperature was deuced to the test temperature of 20 ± 0.5 °C for 24 h and secondary for 96 h with stirring at approx. 100 rpm. The analytical method (SPME-GC-MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. Temperatures were kept constant within ± 0.5 °C. The determined solubilities of the two test vessels difference by more than 15 %, however this was deemed acceptable see below. The analytical method (SPME-GC-MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility was determined 24 and 96 h after reduction to test temperature (20°C). The results obtained for the first measurement (24 h after reduction to test temperature) were slightly outside the calibration range and therefore only used for comparison. A plateau phase was reached. The second set of samples (96 h after reduction to test temperature) gave more scattering results, but as they are comparable to the first measurement they were used to calculate the water solubility. The concentrations, measured for the two longest pre-incubation times (48 and 72 h) of the sampling after 96 h of incubation, differed for 22%. This deviation was considered to be negligible, as the results obtained from an additional sampling (results slightly out of calibration range, therefore not used for evaluation) after 24 h of incubation showed comparable and less differing (7%) results, proving that plateau phase was reached. The water solubility of each isomer contributing to the purity of the test item was determined to be 10.6 mg/L. The water solubility was also determined for the test item as a whole. Under the conditions of this study, the mean water solubility of the substance was determined to be 13.2 mg/L at 20 ± 0.5 °and pH 8.0.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.