Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 801-773-4 | CAS number: 1550-44-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in soil
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in soil: simulation testing
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Transformation products:
- not measured
- Remarks:
- Not applicable in the case of a data waiving
Reference
Description of key information
Data waiving (other justification):
Simulation degradation studies aim at (i) identifying/quantifying degradation products, and (ii) investigating the degradation rate constants and half-lives of the parent subtance and, if applicable of the degradation products.
In the case of 2,2-Difluoroethyl acetate (DFEA):
- With respect to (i), the degradation products have already been identified/quantified in the available OECD 301 C study (see IUCLID section 5.2.1). In the three replicates of the 'DFEA + sludge' treatment, 2,2-Difluoroethanol was formed at 56 to 62% and Difluoroacetic acid was formed at 29 to 31%. Acetic acid is another expected product in the theoretical transformation pathway, but it was not detected in this study likely because it is readily biodegradable. The total formation rate of transformation products (2,2-difluoroethanol and difluoroacetic acid) was ~90%; the rest was supposed to have been volatilized as the test substance or 2,2-difluoroethanol during the 28-day exposure.
- With respect to (ii), the same OECD 301C study has demonstrated a complete disappearance of DFEA. Indeed, based on measurements of residual amounts at the end of the 28-day study, the disappearance rates were calculated to be > 99% for the three replicates of the 'DFEA + sludge' treatment. These analytical measurements gave already robust indications on the mother substance half-life. By the way, determining the half-lives of the degradation products would have no added value considering that all of them have been concluded to be not PBT and not vP/vB (see IUCLID section 2.3).
- In addition, the analytical monitoring performed during the chronic toxicity study on earthworms (see IUCLID section 6.3.1) has demonstrated that it was very difficult, if not impossible, to maintain exposure to DFEA in soil substrate due to its volatility potential. From this, it can be concluded that the biodegradation simulation test in soil will be extremely challenging, if not technically unfeasible.
- Finally, a log Koc > 4 is mentioned in ECHA Guidance R.7b (section R.7.9.4.3, v4.0, June 2017) as an indicator that simulation test in soil may be warranted. The Log Koc of DFEA is clearly below this threshold (see IUCLID section 5.4.1).
Based on the above pool of evidence, it is deemed irrelevant to perfom a biodegradation simulation test in soil with 2,2-Difluoroethyl acetate.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.