Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 933-047-9 | CAS number: 53880-05-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
For the substance no indication was found for a potential of skin or eye irritation/corrosion in validated in vitro tests (OECD 431; OECD 439) or in an in vitro eye irritation test (HET-CAM) according to a testing protocol recommended by ICCVAM (ICVAM Test Method Evaluation Report, 2006).
In vivo, the test substance showed slight effects on rabbit skin (OECD TG 404; erythema scores 1 or 2, fully reversible after 7 days at the latest) and also slight effects on the eyes of rabbits (OECD TG 405; conjunctivae scores 1, fully reversible after 72 hours at the latest). There were no systemic intolerance reactions observed in the two in vivo studies.
For respiratory irritation a subacute (28-days) repeated inhalation toxicity study (see chapter repeated dose toxicity) revealed respiratory irritation at concentrations of 25.8 mg/m³ and above. This was based on histopathology findings and on bronchoalveolar lavage analysis.
Justification for classification or non-classification
According to Regulation (EC) No 1272/2008, Annex I no classification is warranted for skin or eye irritation/corrosion.
According to Regulation (EC) No 1272/2008, Annex I, the substance has to be classified as STOT SE 3 (H335: May cause respiratory irritation).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
