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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 19 - 23, 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study has been performed according to OECD and EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- ISO 7346-1 (Determination of the Acute Lethal Toxicity of Substances to a Freshwater Fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)] - Part 1: Static Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Corsair Clear #12
- Substance type: Soft waxy beige solid
- Physical state: Solid
- Stability under test conditions: stable
- Storage condition of test material: At room temperature in the dark
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0 and 100 mg/l
- Sampling method: 40 ml at t = 0 and t = 96 h
- Sample storage conditions before analysis: refrigerator
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Preparation of the test solution started with loading rates of 100 mg/l. The aqueous mixtures were treated with ultrasonic waves for 5 minutes, followed by a 24-hour magnetic stirring period and a 3 hour stabilisation period. The resulting mixtures were slightly hazy with a floating layer,and undissolved test substance was still present on the cover glasses used for the addition of the test substance to the ISO-medium. Therefore, the mixtures were passed over glass wool, after which they were very slightly hazy. Finally, the solutions were combined and used for the test.
- Controls: Test medium without test substance or other additives
Test organisms
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: carp
- Strain: Cyprinus carpio
- Source: Zodiac, proefacc, "De Haar Vissen", Wageningen University and Research Centre, The Netherlands.
- Age at study initiation (mean and range, SD): not indicated
- Length at study initiation (length definition, mean, range and SD): 2.4 ± 0.1 cm
- Weight at study initiation (mean and range, SD): 0.38 ± 0.07 g
- Method of breeding: F1 from a single parent-pair bred in UV-treated water.
- Feeding during test: no feeding
ACCLIMATION
- Acclimation period: At least 12 days after delivery
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No post exposure observations
Test conditions
- Hardness:
- 180 mg CaCO3 per litre
- Test temperature:
- 21.3 - 22.8°C
- pH:
- 7.4 - 7.8
- Dissolved oxygen:
- 6.3 - 9.6 mg/l
- Nominal and measured concentrations:
- Loading rate 0 mg/l t=0h : TOC = 0.4425 mg/l
Loading rate 0 mg/l t=96h : TOC = 0.2458 mg/l
Loading rate 100 mg/l t=0h : TOC = 0.5312 mg/l
Loading rate 100 mg/l t=96h: TOC = 0.2229 mg/l
The TOC contents in treated samples were comparable to those in control samples, indicating that the actual test substance concentration was very low. This is not unexpected considering the presence of a floating layer and undissolved test substance in the solution, which were removed by passing the solution over glass wool. - Details on test conditions:
- TEST SYSTEM
- Test vessel: 10 litres, all-glass, containing 9 litres of test solution.
- Aeration: Aeration was introduced after 2 days of exposure and continued for 16 hours.
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.30 g fish/litre
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Adjusted ISO medium, formulated using RO-water (tap-water purified by reverse osmosis) with the following composition: CaCl2.2H2O 211.5 mg/l
MgSO4.7H2O 88.8 mg/l
NaHCO3 46.7 mg/l
KCl 4.2 mg/l
- Total organic carbon: 0.44 mg/l
OTHER TEST CONDITIONS
- Adjustment of pH: 7.7 +/- 0.3
- Photoperiod: 16 hours daily
EFFECT PARAMETERS MEASURED: LC50 daily - Reference substance (positive control):
- yes
- Remarks:
- pentachlorophenol
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- loading rate
- Basis for effect:
- mortality (fish)
- Details on results:
- No lethal or sublethal effects were observed in the control or the test concentration.
- Results with reference substance (positive control):
- - Results with reference substance valid: Yes
- Mortality: 0% at 0.10 mg/l; 100% at 0.22 and 0.46 mg/l
- LC50: 96h-LC50 = 0.15 mg/l with a 95% confidence interval between 0.10 and 0.22 mg/l.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions described in this study, Corsair Clear #12 induced no visible effects in carp at a loading rate of 100 mg/l (NOEC).
Due to the very low solubility of Corsair Clear #12 in water, concentration levels that might be toxic for fish could not be reached. Hence the 96h-LC50 was above a loading rate of 100 mg/l.
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