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Diss Factsheets
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EC number: 930-889-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 March - 16 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- (2S)-6-fluoro-2-(oxiran-2-yl)chromane
- EC Number:
- 930-889-9
- Cas Number:
- 1219915-05-5
- Molecular formula:
- C11H11FO2
- IUPAC Name:
- (2S)-6-fluoro-2-(oxiran-2-yl)chromane
- Test material form:
- liquid
- Details on test material:
- Physical state: liquid
Appearence: light brown liquid
1
- Specific details on test material used for the study:
- - Batch n°: I16FB3013
- Analytical purity: 87.5%
- Expiration date: 07 June 2018
- Storage condition: at room temperature
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.535 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- concentration analysed after centrifugation
- Loading of aqueous phase:
- 1.548 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 7.1 - <= 7.2
- Details on results:
- Preliminary test
The content of test item dissolved in the water sample was 0.279 g/L.
Main test
The results for the samples taken at 24, 48 and 72 hours are given in the table in the next section. The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analysed concentrations.
The centrifugation method was not checked. As the maximum difference between the different stirring times was 3.77%, it was considered that the obtained values were not biased by the presence of undissolved test item. A random event as insufficient centrifugation would increase variation between the results of analysis, which was not observed. The integrity of the study was, therefore, not affected.
A small response at the retention time of the test item was detected in the chromatogram of the pretreated blank mixture. The maximum contribution to the samples was 0.044%. It was considered that it has no significant effect on the results of the test samples.
Any other information on results incl. tables
The results for the samples taken at 24, 48 and 72 hours are given in the table underneath.
Stirring time (hours) | Analysed concentration (g/L) | Mean (g/L) | Maximum Difference (MD) (%) | pH |
24 | 0.522 | 0.535 | 3.77 | 7.1 |
48 | 0.540 | 7.1 | ||
72 | 0.542 | 7.2 |
Applicant's summary and conclusion
- Conclusions:
- The flask method was applied for the determination of the water solubility of JNJ-42819543-AAA (T001596).
The water solubility of the test item at 20°C was 0.535 g/L.
The pH of the aqueous samples was 7.1 and 7.2.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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