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EC number: 609-222-8 | CAS number: 3625-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan - Feb 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD guideline under GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-Methoxy-18-methyl-1,3,5(10)-estratrien-17 beta-ol
- EC Number:
- 609-222-8
- Cas Number:
- 3625-82-9
- Molecular formula:
- C20 H28 O2
- IUPAC Name:
- 3-Methoxy-18-methyl-1,3,5(10)-estratrien-17 beta-ol
- Details on test material:
- - Name of test material (as cited in study report): D-ET-Trienol
- Analytical purity: 101.4%
- Lot/batch No.: 21545002
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 200 mg/L
- Based on:
- ThOD/L
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 9
- Sampling time:
- 28 d
- Details on results:
- The reference compound sodium acetate was degraded to 79% on day 6 and to 86% on day 29 (28 days of incubation).
In the toxicity control, the reference compound (sodium acetate) plus the test compound
ZK 46060, was degraded to 49% on day 29 (~ 28 days of incubation), which reflected the
degradation in the individual sets.
Any other information on results incl. tables
Table 1: Biological degradation (cumulative) in percent (corrected for blank O2 consumption) of ZK 46060
Test compound | Concentration | Day of sampling (selected time points) | |||||||
expressed in theoretical O2 | 2 | 6 | 10 | 14 | 18 | 22 | 26 | 29 | |
demand | |||||||||
ZK46060 | 200 mg/L | 5 | 6 | 7 | 8 | 8 | 9 | 9 | 9 |
Reference | 200 mg/L | 32 | 79 | 82 | 84 | 85 | 85 | 86 | 86 |
(sodium acetate) | |||||||||
Toxicity control | 100 mg/L + | 29 | 43 | 45 | 46 | 47 | 47 | 48 | 49 |
(ZK 46060 + sodium acetate) | 100 mg/L |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- In accordance with the OECD, the test compound ZK 46060 is not readily biodegradable
under the conditions of the test and it was not toxic to the microbes of activated sludge. - Executive summary:
The purpose of this study was to determine the ready biodegradability of D-ET-Trienol (ZK 46060), which is an intermediate ofthe synthesis of Norgestrel. The study was conducted in agreement with the OECD test guideline no. 301F.
The test substance was incubated in an aqueous solution including nutrients with microorganisms from a municipal sewage treatment plant for 28 days (start of treatment = day 1). The nutrient solutions were made up of phosphates, magnesium sulphate, iron chloride, ammonium chloride and calcium chloride. The test substance was incubated at a concentration of 200 mg theoretical oxygen demand (ThOD) per litre. Additionally, a reference substance (sodium acetate) was tested in a single set according to the same procedure, in order to verify the viability and activity of the degrading microorganisms. One further set was incubated with sodium acetate at 100 mg ThOD/L (reference substance) plus test compound at 100 mg ThOD/L representing a toxicity control. Furthermore, a blank control was tested in triplicate without any test or reference substance. The biological degradation of the test and reference substances was evaluated by measurement of the O2 consumption during the test period. O2 consumption was continuously monitored and recorded by an automated device. The O2 consumption was calculated as the percentage of total O2 that the test material could theoretically have consumed, based on the molecular formula. The blank O2 consumption was subtracted for correction.
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