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Diss Factsheets
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EC number: 921-136-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2005-09-13 to 2005-12-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- study performed according to OECD 305
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- Qualifier:
- according to guideline
- Guideline:
- other: METI Guideline: Concentration Test on Chemical Substances in Fish
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals/frequency for test organisms: days 0, 7, 14, 21, 24, 28
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): SPAN 20
- Concentration of vehicle in test medium (stock solution and final test solution(s) at different concentrations and in control(s)): 0.16 and 0.016 mg/L
Dose 1: Test item: 0.02 mg/L , Vehicle: 0.16 mg/L
Dose 2: Test item: 0.002 mg/L , Vehicle: 0.016 mg/L
Vehicle Control: test item: - , Vehicle: 0.16 mg/L - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- Weight: 6.01 +/- 0.22 g
Length: 2.20 +/- 0.20 cm
Lot: 50111
Date: 2005-01-11 - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Test temperature:
- 25 +/- 2 °C
- pH:
- 7.7 +/- 0.0
- Dissolved oxygen:
- 7.4 +/- 0.1 mg/L
- Nominal and measured concentrations:
- nominal concentration 0.02 mg/L:
analytically measured concentrations:
day 7: 0.0185 mg/L;
day 14: 0.0213 mg/L
day 21: 0.0183 mg/L
day 24: 0.0188 mg/L
day 28: 0.0168 mg/L
nominal concentration 0.002 mg/L
analytically measured concentrations:
day 7: 0.00198 mg/L
day 14: 0.00198 mg/L
day 21: 0.00189 mg/L
day 24: 0.00198 mg/L
day 28: 0.00187 mg/L - Details on test conditions:
- After acclimatisation period, the fish (Cyprinus carpio) were transferred into the test media under flow through conditions. Exposure concentrations were analytically verified at days 0, 7, 14, 21, 24 and 28. The analytical values show that the nominal concentrations of 0.02 and 0.002 mg/L were maintained at about 100 % using solubiliser, respectively. At days 0, 7, 14, 21, 24 and 28 two fish each were removed from each test group. Body weight was determined.
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.02 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.02 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test material showed no relevant toxic potential at water saturated conditions, thus, having a NOEC corresponding to 100 mg/L nominal concentration.
- Executive summary:
The purpose of this study was to determine the bioconcentration potential of the test material in fish under flow-through conditions. During the GLP compliant test the lethal and other effects in fish were determined during the exposure period of 28 days.
The study was performed according to the OECD Guideline for Testing of Chemicals 305 (Bioconcentration: Flow-through Fish Test) adopted on June 14, 1996 using two test material concentrations for exposure to Cyprinus carpio. Two environmental concentrations of the test material of 0.02 and 0.002 mg/L were used in this study. The exposure was concentration was maintained using SPAN 20 as solubiliser. The concentrations were verified analytically using a HPLC method with UV detection.
There were no mortality and no signs of toxicity detected throughout the study in any dose group up to 28 days of exposure.
The test material showed no relevant toxic potential at water saturated conditions, thus, having a NOEC corresponding to 100 mg/L nominal concentration.
Reference
Description of key information
The test material showed no relevant toxic potential at water saturated conditions, thus, having a NOEC corresponding to 100 mg/L nominal concentration.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- > 100 mg/L
Additional information
The purpose of this study was to determine the bioconcentration potential of the test material in fish under flow-through conditions. During the GLP compliant test the lethal and other effects in fish were determined during the exposure period of 28 days.
The study was performed according to the OECD Guideline for Testing of Chemicals 305 (Bioconcentration: Flow-through Fish Test) adopted on June 14, 1996 using two test material concentrations for exposure to Cyprinus carpio. Two environmental concentrations of the test material of 0.02 and 0.002 mg/L were used in this study. The exposure was concentration was maintained using SPAN 20 as solubiliser. The concentrations were verified analytically using a HPLC method with UV detection.
There were no mortality and no signs of toxicity detected throughout the study in any dose group up to 28 days of exposure.
The test material showed no relevant toxic potential at water saturated conditions, thus, having a NOEC corresponding to 100 mg/L nominal concentration.
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