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EC number: 442-480-8 | CAS number: 182893-11-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 April 2002 - 31 May 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 1.73 g/L
- Temp.:
- 20 °C
- pH:
- >= 3.5 - <= 3.6
- Remarks on result:
- other: MIPKP-T3 peak 2
- Details on results:
- Based on the results of the priliminary test it was decided to centrifuge the samples from the main study three times.
In the main study the test substance was stirred with double distilled water (in triplicate) at a nominal concentration of 1 g/ml. After each stirring period, the water mixture was still a two-phase system (water and test substance).
Duplicate samples were taken from each water mixture after 24, 48 or 72 hours of stirring. The supernatants obtained after three successive centrifugation steps (3500 g, 5 min., 20°C) were analysed. The temperature of the climate room was 20.0 ± 0.4°C during the performance of the test. The analytical results for the samples are summarised in the attached Table. No (significant) concentrations were measured in the blank water mixture for the components of concern. - Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
During the test, hydrogen peroxide is formed as a result of the reaction of the other peroxidic compounds with water. Based on Hydrogen peroxide, it was determined to be miscible with water in at least a 1:1 (v:v) ratio.
During the test MIPK is formed as a result of the reaction of the other peroxidic compounds with water. Based on MIPK, the water solubility was determined to be ≥ 230 g/l.
Based on MIPKP-T4, the water solubility was estimated to be ≥ 201 g/l.
Based on MIPKP-T3 peak 1, the water solubility was determined to be 2.53 g/l.
Based on MIPKP-T3 peak 2, the water solubility was determined to be 1.73 g/l. - Executive summary:
Guidelines and test method
The flask method was used to determine the water solubility and was based on the following guidelines:
OECD guideline for testing of chemicals no. 105: "Water Solubility", Adopted July 27,1995.
EEC Directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.6: "Water solubility". EEC Publication no. L383, December 1992.
Quantification
Measurements were performed on the following components: Hydrogen peroxide, MIPK, MIPKP-T4 and MIPKP-T3. Due to the fact that DMP, which was used for preparation of this formulation, is a very well known compound, which cannot be determined in the same chromatographic run as the other compounds due to a large difference in sensitivity (see also Notox Project 338805 "Development and validation of an analytical method for Trigonox R-938"), analyses were not based on this compound.
Test results
After each stirring period (17 days; preliminary test or 24, 48 or 72 hours; main study), there was still a two-phase system (water and test substance). Test temperature: 20.0 ± 0.5°C (preliminary test) and 20.0 ± 0.4°C
(main study). Analytical measurements on each of the components of
concern in the water phase gave the following results:
During the test, hydrogen peroxide is formed as a result of the reaction of the other peroxidic compounds with water. Based on Hydrogen peroxide, it was determined to be miscible with water in at least a 1:1 (v:v) ratio.
During the test MIPK is formed as a result of the reaction of the other peroxidic compounds with water. Based on MIPK, the water solubility was determined to be ± 230 g/l. Based on MIPKP-T4, the water solubility was estimated to be ± 201 g/l. Based on MIPKP-T3 peak 1, the water solubility was determined to be 2.53 g/l. Based on MIPKP-T3 peak 2, the water solubility was determined to be 1.73 g/l.
Reference
After each stirring period (17 days; preliminary test or 24, 48 or 72 hours; main study), there was still a two-phase system (water and test substance). Analytical measurements on each the components of concern in the water phase gave the following results: Hydrogen peroxide appeared to be the component with the highest water solubility. The preliminary test showed that at a test substance:water ratio of 1:1 (v:v) the concentrations analysed were a factor of 2 higher than at a test substance:water ratio of 1:2 (v:v). At both concentration levels, the concentrations analysed were far above the nominal concentration, indicating that hydrogen peroxide might be formed due to reaction of the other compounds with
water. The main study confirmed this assumption and showed that hydrogen peroxide concentrations increased with stirring time. After 24 hours of stirring, the concentrations analysed were already higher than the nominal concentration of 1 g/ml (i.e. a test substance:water ratio of 1:1 (v:v». Based on Hydrogen peroxide, it was determined to be miscible with water in at least a 1:1 (v:v) ratio.
Both MIPKP-T4 and MIPK appeared to be good water soluble substances. Based on the results form the main study, it was concluded that MIPKP-T4 decomposes with time, whereas MIPK seems to be a decomposition product. Based on MIPK, the water solubility was determined to be ± 230 g/l, based on MIPKP-T4, the water solubility was estimated to be ± 201 g/l (maximum concentrations found in the aqueous samples).
MIPKP-T3 peak 1 and MIPKP-T3 peak 2 appeared to be the least water soluble components. For both components, a slight decrease in concentration was observed over the duration of the main study. Therefore, the solubility of the test substance based on MIPKPT3 peak 1 and MIPKP-T3 peak 2 is reported as the average of the 24 hours samples. Based on MIPKP-T3 peak 1, the water solubility was determined to be 2.53 g/l. Based on MIPKP-T3 peak 2, the water solubility was determined to be 1.73 g/l.
Description of key information
After each stirring period (17 days; preliminary test or 24, 48 or 72 hours; main study), there was still a two-phase system (water and test substance).
Test temperature: 20.0 ± 0.5°C (preliminary
test) and 20.0 ± 0.4°C (main study). Analytical measurements on each of
the components of concern in the water phase gave the following results:
During the test, hydrogen peroxide is formed as a result of the reaction of the other peroxidic compounds with water.
Based on Hydrogen peroxide, it was determined to be miscible with water in at least a 1:1 (v:v) ratio.
During the test MIPK is formed as a result of the reaction of the other peroxidic compounds with water.
Based on MIPK, the water solubility was determined to be ± 230 g/l. Based on MIPKP-T4, the water solubility was estimated to be ± 201 g/l. Based on MIPKP-T3 peak 1, the water solubility was determined to be 2.53 g/l. Based on MIPKP-T3 peak 2, the water solubility was determined to be 1.73 g/l.
Key value for chemical safety assessment
- Water solubility:
- 1.73 mg/L
- at the temperature of:
- 20 °C
Additional information
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