Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 264-935-8 | CAS number: 64519-44-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 August 2017 - 18 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study has been conducted according to OECD/EU guideline and under GLP. No significant deviation is reported. The substance is adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- Commission Regulation (EC) No 761/2009 of 23. July 2009, published on 24. Aug. 2009 Method A.4: “Vapour Pressure”
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GLP certificate (inspected on 15 to 16 November 2017 / signed on 15 May 2018)
- Type of method:
- effusion method: Knudsen cell
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.001 Pa
- Remarks on result:
- other:
- Remarks:
- extrapolated from the regression
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other:
- Remarks:
- extrapolated from the regression
- Conclusions:
- Low volatility.
- Executive summary:
The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, effusion method (Knudsen cell). Determinations were conducted at 30, 45, 60, 75, 90 and 105 °C. Experiment 1 (nominal temperature 30 °C) showed no reproducible weight loss. These measurements were not used for calculations.
The other temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P): the graph shows a straight line with a correlation coefficient (r) of -0.9934.
Vapour pressure at 20 and 25 °C was extrapolated from the regression.
The vapour pressure of the test item has been determined to be 0.000424 Pa at 20°C and 0.000744 Pa at 25 °C.
Reference
The mass of sample used in the respective cell, the data of the evaluated experiments and calculation results were reported in the report.
Note that Experiment 1 (nominal temperature 30 °C) showed no reproducible weight loss. Therefore these values were not used for calculations.
After the third measurement of 105 °C the determination was finished as enough values were given and the cells were nearly empty.
A summary of the mean of all measured values for temperature and vapour pressure is reported below :
Table 4.6/1: Vapour pressure results, in Pa
T | T | p | Stand, Dev, p | RSD p |
°C | K | Pa | Pa | % |
45 | 318,2 | 7,63E-03 | 1,52E-03 | 19,90% |
60 | 333,2 | 1,96E-02 | 5,67E-03 | 29,00% |
75 | 348,2 | 6,56E-02 | 3,85E-03 | 5,90% |
90 | 363,2 | 2,75E-01 | 1,79E-02 | 6,50% |
105 | 378,2 | 9,52E-01 | 1,81E-02 | 1,90% |
These measured values were evaluated as follows:
Table 4.6/2: Evaluation of the data:
Parameter |
T |
Mean p |
1/T |
log p |
Unit |
K (°C) |
Pa |
1/K |
log Pa |
|
318.2 K (45.0°C) |
7.63E-03 |
3.1427E-03 |
-2.1173 |
333.2 K (60.0°C) |
1.96E-02 |
3.0012E-03 |
-1.7079 |
|
348.2 K (75.0°C) |
6.56E-02 |
2.8719E-03 |
-1.1830 |
|
363.2 K (90.0°C) |
2.75E-01 |
2.7533E-03 |
-0.5606 |
|
378.2 K (105.0°C) |
9.52E-01 |
2.6441E-03 |
-0.0213 |
A graph with log P vs. 1/T was plotted. Since the values were correlated by a linear relation, the data could be fitted by linear regression:
slope = -4264.5
intercept = 11.1750
Correlation Coefficient r = -0.9934
Coefficient of Determination r2 = 0.9868
The linear regression of log P vs. 1/T gave a correlation coefficient r of -0.9934, showing good repeatability and precision. In addition, the vapour pressure measured for the positive control at 30°C met the validity criteria. Therefore, the determination is considered as valid.
Finally, the following vapour pressures at 20°C and at 25°C were calculated for the test item, from the regression equation (extrapolation):
Vapour pressure at 20°C: 0.000424 Pa
Vapour pressure at 25°C: 0.000744 Pa
Description of key information
Low volatility.
Key value for chemical safety assessment
- Vapour pressure:
- 0.001 Pa
- at the temperature of:
- 25 °C
Additional information
A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. The result is retained as key data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.