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EC number: 258-007-1 | CAS number: 52558-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Validated QSAR model.
- Justification for type of information:
- QSAR prediction.
- Principles of method if other than guideline:
- Calculation based on BCFBAF v3.01, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Test organisms (species):
- other: Fish
- Route of exposure:
- aqueous
- Test type:
- other: calculation
- Water / sediment media type:
- natural water: freshwater
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF
- Estimation software: BCFBAF v3.01
- Result based on calculated log Pow of: 5.08 (estimated, KOWWIN v.1.68) - Type:
- BCF
- Value:
- 306.9 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Arnot Gobas (including biotransformation rate estimates, upper trophic)
- Type:
- BAF
- Value:
- 308 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Arnot Gobas (including biotransformation rate estimates, upper trophic)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Validated QSAR model.
- Justification for type of information:
- QSAR prediction.
- Principles of method if other than guideline:
- Calculation based on BCFBAF v3.01, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Test organisms (species):
- other: Fish
- Route of exposure:
- aqueous
- Test type:
- other: calculation
- Water / sediment media type:
- natural water: freshwater
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF
- Estimation software: BCFBAF v3.01
- Result based on calculated log Pow of: 5.08 (estimated, KOWWIN v.1.68) - Type:
- BCF
- Value:
- 10 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Regression based estimate
Referenceopen allclose all
Description of key information
BCF (regression method): 10 L/kg (BCFBAF 3.01)
BCF (Arnot-Gobas method): 306.9 L/kg (BCFBAF 3.01)
BAF (Arnot-Gobas method): 308 L/kg (BCFBAF 3.01)
Key value for chemical safety assessment
Additional information
N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) has a low potential for bioaccumulation at environmentally relevant pH based on its log D values (used for ionisable substances instead of log Kow) of 1.52 at pH 7 and 0.63 at pH 9 (SPARC v4.6), indicating low lipophilicity at the environmentally relevant pH of 7 to 9. According to REACh regulation (EC) No 1907/2006, substances with log Kow ≤ 3.0 have a low potential for bioaccumulation. Thus, further testing is not required in accordance with Annex IX, column 2, 9.3.2. of Regulation (EC) No. 1907/2006.
Furthermore, the predicted BCF values also indicate that the potential for bioconcentration in aquatic organisms is low. The estimated BCF values are 10 – 306.9 L/kg wet-wt (BCFBAF v3.01), which are well below the cut-off value of 2000 L/kg wet-wt for bioaccumulative and 5000 L/kg wet-wt for very bioaccumulative substances, as laid down by section 1 of Annex XIII of REACH Regulation (EC) No. 1907/2006. In addition, toxicokinetic considerations with regard to absorption, distribution, metabolisation and excretion of the substance provide further evidence for a low potential for bioaccumulation. While absorption after oral uptake is considered likely, systemic distribution, accumulation and metabolisation of the substance is not anticipated and urinary excretion is expected to be an important and rapid excretion pathway based on experimental mammalian studies with structurally similar substances (for further details, please refer to the toxicokinetic statement in IUCLID section 7.1).
Moreover, N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) is readily biodegradable. According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs) (ECHA, 2016). Therefore, only low concentrations of the substance are likely to be released into the environment through conventional STPs, if at all, and whatever fraction is released will not persist. Thus, exposure of aquatic organisms and bioavailability in the environment is expected to be low.
In conclusion, N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) is expected to have a low potential for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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